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Tim-3 mRNA expression in peripheral blood lymphocytes from asthmatic patients
Xiaoxia LU, Weikun HU, Shengdao XIONG, Guopeng XU, Fen LAN
《医学前沿(英文)》 2009年 第3卷 第2期 页码 187-190 doi: 10.1007/s11684-009-0033-6
关键词: asthma airway inflammation peripheral blood lymphocyte Tim-3
Impact of HBV replication in peripheral blood mononuclear cell on HBV intrauterine transmission
null
《医学前沿(英文)》 2017年 第11卷 第4期 页码 548-553 doi: 10.1007/s11684-017-0597-5
This study determined the effect of hepatitis B virus (HBV) replication in peripheral blood mononuclear cell (PBMC) from HBsAg-positive mothers on HBV intrauterine transmission. A total of 150 HBsAg-positive mothers and their neonates were recruited in this study. Within 24 h after birth, HBV serological markers, serum HBV DNA, PBMC HBV relaxed circular DNA (rcDNA), and covalently closed circular DNA (cccDNA) were measured in the HBsAg-positive mothers and their neonates before passive-active immune prophylaxis. The relationship between HBV replication in PBMC and HBV intrauterine transmission was examined through Chi-square test and logistic regression. The rate of HBV intrauterine transmission was 8.00% (12/150) in the 150 neonates born to HBsAg-positive mothers. The positivities of PBMC HBV rcDNA and cccDNA in the HBsAg-positive mothers were 36.67% (55/150) and 10% (15/150), respectively. Maternal PBMC HBV cccDNA was a risk factor of HBV intrauterine transmission (OR= 6.003, 95% CI: 1.249–28.855). Maternal serum HBeAg was a risk factor of PBMC HBV rcDNA (OR= 3.896, 95% CI: 1.929–7.876) and PBMC HBV cccDNA (OR= 3.74, 95% CI: 1.186–11.793) in the HBsAg-positive mothers. Administration of hepatitis B immune globulin was a protective factor of PBMC HBV cccDNA (OR= 0.312, 95% CI: 0.102–0.954) during pregnancy. The positivity of PBMC HBV rcDNA was related to that of cccDNA in the HBsAg-positive mothers (c2=5.087, P= 0.024). This study suggests that PBMC is a reservoir of HBV and an extrahepatic site for virus replication and plays a critical role in HBV intrauterine transmission.
关键词: PBMC HBV cccDNA HBV rcDNA HBV intrauterine transmission
Haiyan WANG, Qiaoxia ZHANG, Lilin YIN, Xiangdong LIU, Shuhong ZHAO, Mengjin ZHU, Changchun LI
《农业科学与工程前沿(英文)》 2017年 第4卷 第3期 页码 342-352 doi: 10.15302/J-FASE-2017162
Xiu-Liang TAO MM, Sheng-Hao TU MD, Ri-Bo XIONG MM, Yong-Hong HU BM,
《医学前沿(英文)》 2010年 第4卷 第2期 页码 220-224 doi: 10.1007/s11684-010-0025-6
关键词: arthritis rheumatoid molonuclear cells tumor necrosis factor gene polymorphisms triptolid
Non-invasive continuous blood pressure monitoring: a review of current applications
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 91-101 doi: 10.1007/s11684-013-0239-5
Blood pressure monitoring has come a long way from the initial observations made by Reverend Hales in the 18th century. There are none that deny the importance of monitoring perioperative blood pressure; however, the limited ability of the current prevalent technology (oscillometric blood pressure monitoring) to offer continuous blood pressure measurements leaves room for improvement. Invasive monitoring is able to detect beat-to-beat blood pressure measurement, but the risks inherent to the procedure make it unsuitable for routine use except when this risk is outweighed by the benefits. This review focuses on the discoveries which have led up to the current blood pressure monitoring technologies, and especially the creation of those offering non-invasive but continuous blood pressure monitoring capabilities, including their methods of measurement and limitations.
关键词: non-invasive blood pressure monitoring continuous blood pressure monitoring invasive blood pressure monitoring Riva-Rocci technique oscillometric Pe?áz technique arterial tonometry pulse transit time
外周血免疫特征预测肝内胆管癌患者化疗敏感性 Article
吴彤, 杨应成, 郑博, 施学兵, 李炜, 马文聪, 王珊, 李祉萱, 朱妍静, 吴建民, 汪凯婷, 赵燕, 伍睿, 隋成军, 莘似韵, 吴璇, 陈磊, 袁振刚, 王红阳
《工程(英文)》 2021年 第7卷 第10期 页码 1381-1393 doi: 10.1016/j.eng.2021.01.014
肝内胆管癌(ICC)是第二常见肝癌。化疗仍然是晚期ICC患者的主要治疗方法,但是化疗敏感性因人而异。在本研究中,我们使用飞行时间质谱仪(CyTOF)在单细胞水平上建立ICC患者在化疗前、化疗中和化疗后指定时间点外周血单核细胞(PBMC)的免疫谱;应用多重免疫荧光染色展现某些特定免疫亚群的空间分布;使用组织微阵列(TMA)评估患者预后。本研究共招募了20名接受吉西他滨(GEM)治疗的ICC患者,其中8例对化疗反应良好(R),12例无反应(NR)。我们观察到化疗后患者PBMC组成发生了巨大变化,比如CD4/CD8 双阳性T细胞(DPT)水平增加。治疗前CD4+CD45RO+CXCR3+T细胞水平较高的患者对化疗反应良好。我们的研究确定了T细胞亚群的百分比与患者化疗反应性之间存在正相关关系,这表明通过评估PBMC中细胞亚群的比例来预测ICC患者化疗反应性是可行的。
TANG Zhongzhi, LI Junyao, YANG Jianhong
《医学前沿(英文)》 2008年 第2卷 第2期 页码 178-181 doi: 10.1007/s11684-008-0033-y
Autologous peripheral hematopoietic stem-cell transplantation in a patient with refractory pemphigus
SUN Ledong, SUN Jing, ZENG Kang, MENG Fanyi, DIAO Youtao, XU Dan, HUANG Liang, ZHAO Jie, Liu Qifa
《医学前沿(英文)》 2008年 第2卷 第2期 页码 191-194 doi: 10.1007/s11684-008-0036-8
关键词: serological activity leukapheresis peripheral hematopoietic cyclophosphamide resistance
White blood cell count and the incidence of hyperuricemia: insights from a community-based study
Jian Liu, Pingyan Shen, Xiaobo Ma, Xialian Yu, Liyan Ni, Xu Hao, Weiming Wang, Nan Chen
《医学前沿(英文)》 2019年 第13卷 第6期 页码 741-746 doi: 10.1007/s11684-017-0579-7
关键词: white blood cell count hyperuricemia chronic kidney disease inflammation
大鼠周围神经诱发脑皮层电位时空图——一种研究脑对周围神经反应模式的新方法 Article
殷晓峰, 邓玖旭, 陈博, 金博, 谷馨怡, 齐志丹, 冷坤鹏, 姜保国
《工程(英文)》 2022年 第14卷 第7期 页码 147-155 doi: 10.1016/j.eng.2021.04.018
将大脑作为一个整体,观察周围神经受到刺激后大脑反应的动态过程,是深入了解脑功能的基础,也是一个科学难题。本研究发展了一种新型大鼠脑皮层诱发电位微创正交记录方法,结果显示,在该方法下,刺激大鼠正中神经、尺神经和桡神经及其分支,首次获得了可重复、具有不同波形特点、可辨别的脑皮层诱发电位图谱,并将其时空变化规律以可视化的方式呈现出来。此外本研究也记录了正中神经离断4个月后,大鼠脑皮层诱发电位的变化。结果表明,大脑皮层对周围神经刺激的反应具有精确和可重复的时空顺序。本实验方法和波形图谱可作为测试平台用于探索周围神经系统和脑中枢神经系统之间的整体功能交互与动态重塑的时相机制。
Heyun WANG, Yakai FENG, Marc BEHL, Andreas LENDLEIN, Haiyang ZHAO, Ruofang XIAO, Jian LU, Li ZHANG, Jintang GUO
《化学科学与工程前沿(英文)》 2011年 第5卷 第3期 页码 392-400 doi: 10.1007/s11705-011-1202-0
关键词: electrospinning artificial blood vessels scaffold polyurethane gelatin nanofiber hemocompatibility
Study of blood exposure-related mental health illness among clinical nurses
null
《医学前沿(英文)》 2017年 第11卷 第1期 页码 147-151 doi: 10.1007/s11684-016-0481-8
Nurses are subjected to high amount of stress in the medical setting, and work-related stress often leads to mental problems. This study aims to investigate the mental health status of nurses exposed to blood through needlestick injuries. A total of 302 nurses working in the hospital of Guangdong, China, participated in this study. Out of the 302 nurses, 140 did not experience any needlestick injuries during the previous week, whereas 162 nurses experienced needlestick injuries. The General Health Questionnaire (GHQ)-28 Standardized Questionnaire, which uses physical, anxiety, social function, and depression subscales, was used in this study. No significant difference between nurses exposed to blood and nurses not exposed to blood was found in terms of gender, age, length of employment, and civil status (P>0.05). Results from the GHQ-28 Standardized Questionnaire showed that 75.9% (123/162) of nurses exposed to blood were suspected to suffer from mental disorders, whereas 40% (56/140) of nurses not exposed to blood were suspected to suffer from mental disorders. The mean mental health scores of nurses exposed to blood and those not exposed were 8.73±7.32 and 5.69±5.70, respectively. From these results, we can conclude that blood exposure from needlestick injuries leads to higher prevalence of depression, anxiety, and stress symptoms in nurses. This finding highlights the importance of providing efficient, adequate, and appropriate support services after nurses are exposed to blood from needlestick injuries.
关键词: blood exposure needlestick injuries mental health nurses
Endostatin specifically targets both tumor blood vessels and lymphatic vessels
Wei Zhuo, Yang Chen, Xiaomin Song, Yongzhang Luo
《医学前沿(英文)》 2011年 第5卷 第4期 页码 336-340 doi: 10.1007/s11684-011-0163-5
关键词: endostatin angiogenesis lymphangiogenesis nystatin internalization tumor
Intracellular trehalose improves the survival of human red blood cells by freeze-drying
HE Hui, LIU Baolin, HUA Zezhao, LI Chuan, WU Zhengzheng
《能源前沿(英文)》 2007年 第1卷 第1期 页码 120-124 doi: 10.1007/s11708-007-0014-x
陈灏珠,金雪娟
《中国工程科学》 2002年 第4卷 第11期 页码 1-6
回顾分析50年来我国健康人群血脂水平的变化,结果显示血总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-C)随年龄而增高,50岁以前男女间无差别,50岁以后女性高于男性,城市居民高于农村居民;高密度脂蛋白胆固醇(HDL-C)随年龄的变化不明显,男性低于女性;血TC、TG和LDL-C随年代而增高,20世纪90年代末达最高峰,而HDL-C则下降;血TC高于正常者(>200~220 mg/dL)男性占17.8 %~54.9 %,女性占14.9 %~53.4 %,也随年代而增多;血脂水平的变化与饮食结构转变为低碳水化合物、高脂肪、高胆固醇有关。对策:恢复健康的饮食习惯,摄取平衡饮食;建立良好生活习惯,减少其他心血管病危险因素,特别建议进行体育锻炼;已有血脂异常,经饮食调节和体育锻炼3个月以上仍未见好转者,宜接受调脂药物治疗。
标题 作者 时间 类型 操作
Tim-3 mRNA expression in peripheral blood lymphocytes from asthmatic patients
Xiaoxia LU, Weikun HU, Shengdao XIONG, Guopeng XU, Fen LAN
期刊论文
Impact of HBV replication in peripheral blood mononuclear cell on HBV intrauterine transmission
null
期刊论文
Transcriptomic basis of neutrophil ratio variation induced by poly I:C stimulation in porcine peripheralblood
Haiyan WANG, Qiaoxia ZHANG, Lilin YIN, Xiangdong LIU, Shuhong ZHAO, Mengjin ZHU, Changchun LI
期刊论文
Inhibition of TNF-alpha secretion from peripheral blood monocular cells by triptolid is associated with
Xiu-Liang TAO MM, Sheng-Hao TU MD, Ri-Bo XIONG MM, Yong-Hong HU BM,
期刊论文
外周血免疫特征预测肝内胆管癌患者化疗敏感性
吴彤, 杨应成, 郑博, 施学兵, 李炜, 马文聪, 王珊, 李祉萱, 朱妍静, 吴建民, 汪凯婷, 赵燕, 伍睿, 隋成军, 莘似韵, 吴璇, 陈磊, 袁振刚, 王红阳
期刊论文
Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure, lipid profileand blood glucose level
TANG Zhongzhi, LI Junyao, YANG Jianhong
期刊论文
Autologous peripheral hematopoietic stem-cell transplantation in a patient with refractory pemphigus
SUN Ledong, SUN Jing, ZENG Kang, MENG Fanyi, DIAO Youtao, XU Dan, HUANG Liang, ZHAO Jie, Liu Qifa
期刊论文
White blood cell count and the incidence of hyperuricemia: insights from a community-based study
Jian Liu, Pingyan Shen, Xiaobo Ma, Xialian Yu, Liyan Ni, Xu Hao, Weiming Wang, Nan Chen
期刊论文
gelatin-heparin nanofibrous scaffolds formed by a bi-layer electrospinning technique as potential artificial blood
Heyun WANG, Yakai FENG, Marc BEHL, Andreas LENDLEIN, Haiyang ZHAO, Ruofang XIAO, Jian LU, Li ZHANG, Jintang GUO
期刊论文
Endostatin specifically targets both tumor blood vessels and lymphatic vessels
Wei Zhuo, Yang Chen, Xiaomin Song, Yongzhang Luo
期刊论文
Intracellular trehalose improves the survival of human red blood cells by freeze-drying
HE Hui, LIU Baolin, HUA Zezhao, LI Chuan, WU Zhengzheng
期刊论文